The ketamine, ketamine+diazepam, xylazine, compound xylazine, Lumianning and 846 complex were used as anaesthetic and restraint drugs to treat 163 clinical cases in twenty two tigers including six South China Tigers ,thirteen Siberian Tigers and three Bengal Tigers, and the restraint efficacy of the six preparations were compared.The results showed that the efficacy of compound xylazine and Lumianning was the best, the xylazine and ketlamine+diazepam running second, and ketamine and 846 complex was the poorest. The restraint efficacy of the six drugs did not differ significantly when they were used for restraint in the three subspecies of tigers.