To understand the difference of the nucleoprotein (N) gene and glycoprotein (G) gene between the strain of pig origin and other rabies viruses. The N and G genes of rabies virus isolated from the brain of a rabid pig in Guangdong Province were amplified by RT-PCR, cloned, sequenced and compared with the genes of other rabies virus. The results showed that the sequence of nucleotides and amino acids of N genes of GD-SH01 shared 84.3%-98.0% and 92.5%-99.3% similarity，and G genes of GD-SH01 shared 80.4%-98.2% and 87.8%-99.6% similarity, respectively, compared to other viruses.