Objective To determine resistance of brown planthopper, Nilaparvata lugens (Stål), to common insecticides in Guangdong Province, so as to provide a basis for controlling N. lugens. Method N. lugens were collected from Guangzhou, Leizhou, Liangzhou, Nanxiong, Haifeng, Dapu and Huaiji of Guangdong Province. The resistance of N. lugens to buprofezin, imidacloprid, thiamethoxam and pymetrozine were determined by dipping rice seedlings in laboratory. Result N. lugens populations in Guangdong were extremely highly resistant to imidacloprid with the resistance ratios from 161.9 to 3 576.4, highly to extremely highly resistant to buprofezin with the resistance ratios from 93.4 to 1 497.8, and to thiamethoxam with the resistance ratios from 61.0 to 517.8, and less sensitive to pymetrozine with a medium level of resistance ratios from 3.7 to 11.0. Conclusion Imidacloprid, bprofezin and thiamethoxam should be suspended, and pymetrozine should be restricted to use on rice, so as to slow down the insecticide resistance and properly control N. lugens.