This paper was aimed to study the effect of timed artificial insemination technology on the reproductive performance of Duroc sows. Reproductive performances of normal estrus gilts, anestrus gilts and weaned sows were determined after using timed artificial insemination technology in a pig farm managed by Guangdong Wens Foodstuffs Group Co., Ltd in East China. The results showed that the estrus rate, fertilization rate, pregnancy rate, reproductive rate and reproductive efficiency of normal estrus gilts and weaned sows was significantly higher than the control group. The timed artificial insemination technology had a certain promoting effect on the reproductive efficiency of anestrus gilts, reaching 4.06 pigs per sow. The timed artificial insemination technology can improve the reproductive performance of Duroc sows to a certain extent.