To meet the neeeds of rapid development of pig industry of Wens Group, we carried out the production, application and extension research on five-breed hybrid pig WS501. Preliminary extension area covered seven branch companies in Guangdong, Guangxi, Fujian, Jiangsu, Hubei, Anhui and other provinces(regions). The farrowing results showed that W352 sows had the characteristics of long and tall body, small head, moderate muscle, good abdomen, more teats and good reproductive performance. Compared with two-line hybrid sows at the same period, teats of W352 sows were 0.3-0.8 more,total number born were 0.3-0.9 more, number born alive were 0.3-0.8 more,number born robust were 0.2-0.7 more,and piglets per sow per year (PSY) were 0.8-1.8 higher. More than 2.6 million head of five-line hybrid pigs(WS501) were on the market. From the reaction of farmer and market, WS501 pigs were popular in the market because of their fast growth, high lean meat percentage, large market weight and good consistency.