ABSTRACT: In order to clarify the economic growth effect of Guangdong's fiscal expenditure, firstly, a cointegration and error correction model is constructed based on the time series data of Guangdong's per capita fiscal expenditure and per capita GDP data package from 1990 to 2014. Secondly, the data are processed and analyzed by Stata software. The results show that the amplification effect of Guangdong's fiscal expenditure on economic growth is very obvious. It also has strong time and regional characteristics. Finally, the paper puts forward measures to enlarge the amplification effect of Guangdong's fiscal expenditure on economic growth: (1) Guangdong should continue to increase its fiscal expenditure to ensure sustainable and healthy economic development in the future; (2) Guangdong's fiscal expenditure should not only focus on the present, but also on the future; (3) Guangdong's fiscal expenditure should take into account the Pearl River Delta, western and Eastern Guangdong as a whole and incline to the mountainous areas appropriately. To ensure efficiency and fairness.