抗生素对微生物发酵生产L—苹果酸过程中污染杂菌的抑制效果测定
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EFFECTIVENESS OF ANTIBIOTICS ON POLLUTION MICROBES OF FERMENT PRODUCTION PROCESS OF L-MALIC ACID
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    摘要:

    试验模拟L-苹果酸发酵上罐的温度、pH值以及通气等条件,利用振荡培养法测定庆大霉素、链霉素、硫酸核糖霉素,硫酸小诺霉素等4种抗生素对污染杂苗的最低抑制浓度,并进行两次加菌试验,结合平板检菌加以验证。结果表明庆大霉素的抑菌作用最强,其次是硫酸小诺霉素。庆大霉素的MIC为0.4mg/L,经两次加菌后,有效浓度为0.8mg/L,通过在240和1700L发酵罐上的实际应用,有效地防止了杂菌污染,证明此法是

    Abstract:

    A study on the effects of minimal inhibitory concentration of several antibiotics, including Gentamicin, Streptomycin, Ribostamycin Sulfate, and Sagamicin Sulfate, on pollution microbes of L-malic acid was conducted in this paper. The experiment of the simulation ferment process with the same temperature, pH value and ventilation conditions in vibration culture with twice pollution microbes was carried out added and the results were validated by agar plate culture. It was showed that Gentamicin had the strongest inhibitory effectiveness and Sagamicin Sulfate the second. The minimal inhibitory concentration of Gentamicin was 0.4 mg/L, and after twice pollution microbes added, the effective concentration was 0.8 mg/L. The result was used for the ferment processing practically with the fermentation tanks of 240 and 1700 L, and proved to be valid for L-malic acid fermentation.

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李盾 邓穗儿.抗生素对微生物发酵生产L—苹果酸过程中污染杂菌的抑制效果测定[J].华南农业大学学报,1997,(2):30-34

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