【目的】探讨中药组方“虎诃紫”的毒性及对鸡白痢沙门菌 Salmonella pullorum 的疗效.【方法】根据兽药研究技术指导原则，对中药组方提取物进行小鼠灌胃急性毒性试验，同时以人工诱发鸡白痢沙门菌的雏鸡感染模型，按高、中、低（4.20、1.62、0.48 g/d）剂量饮水给药，连续 7 d，评价中药组方“虎诃紫”颗粒剂的疗效.【结果和结论】急性毒性试验给药剂量大于 5 000 mg/kg，小鼠无死亡，即LD50＞5 000 mg/kg，对其进行中药组方提取物最大耐受量的测定，其最大耐受量为40 g/kg；高剂量颗粒剂组治愈率和有效率分别是75.0%和83.3%，中剂量颗粒剂组的治愈率和有效率分别是72.7%和81.8%，低剂量颗粒剂组的治愈率和有效率分别为62.5%和75.0%，而感染对照组的死亡率为40%；χ2 检验表明“虎诃紫”颗粒剂高、中剂量组与感染对照组的死亡率差异显著（P<0.05）.结果表明：中药组方无毒；高剂量组的治愈率、有效率都高于中、低剂量组，高、中剂量组的死亡率都低于感染对照组，说明高、中剂量组对鸡白痢沙门菌的死亡具有一定的保护作用.
【Objective】To investigate the toxicity of compound traditional Chinese medicine “Huhezi” and observe its efficacy in chickens experimentally infected with Salmonella pullorum. 【Methods】According to the veterinary drug research technical guidelines，the acute toxicity test was carried out in mice by gavage with “Huhezi”extracts. To evaluate the efficacy of “Huhezi” granules，the chickens experimentally infected with Salmonella pullorum were treated at a dosage of 4.20，1.62，0.48 g/d respectively by drinking water for 7 successive days.【Result and conclusion】The dose of acute toxicity test of “Huhezi”extracts was over 5 000 mg/kg. No death was observed in mice，revealing LD50> 5 000 mg/kg. The maximum tolerated dose was 40 g/kg. The cure rates of different dose granules groups were 75.0%，72.7%，62.5% and the effective rates were 83.3%，81.8%，75.0% respectively， while the mortality rate of infected control group was 40%. The result of χ2 test showed that the mortality rate of high and medium dose group of “Huhezi” granule was significanty different from that of the infected control group. The results indicate that compound traditional Chinese medicine extracts are non-toxic， and the high and medium dose of “Huhezi” granules have certain protection to infected death of S. pullorum， with cure rates and effective rates of high dose group being higher than that of medium and low dose groups， the mortality rates of high and medium dose groups being lower than that of the infected control groups.