目的 探究宫内发育迟缓(IUGR)对生长肥育猪免疫器官和血浆细胞因子含量的影响。方法 选择36头体况相近的妊娠母猪，分娩后从每窝仔猪中选取IUGR仔猪和正常初生质量仔猪(作为对照)各1头，断奶后2组饲喂相同基础饲粮。分别于对照组猪平均体质量达25、50和100 kg时，每组随机选取7头，前腔静脉采血，测定血浆细胞因子含量；每组取12头屠宰，分离肝脏、脾脏和肾脏并称质量，计算器官系数。结果 与相同体质量对照组相比，IUGR组肝脏、脾脏和肾脏质量在25 kg体质量阶段分别降低32.63%、35.07%和34.28% (P<0.01)，在50 kg体质量阶段分别降低22.68%、40.05%和33.03% (P<0.01)，在25和50 kg体质量阶段血浆白介素IL-1β含量分别降低20.66%和27.21% (P<0.05)；在50 kg体质量阶段IUGR组肝脏系数升高16.25% (P<0.05)，IL-1β/IL-10值降低40.67% (P<0.01)；与100 kg体质量对照组相比，100 kg体质量IUGR组肝脏系数升高10.94% (P<0.05)，脾脏系数升高21.74% (P<0.01)，肝脏和肾脏质量分别降低13.97% (P<0.01)和17.51% (P<0.05)。结论 IUGR能改变生长育肥猪的肝脏、脾脏和肾脏的器官系数和质量，降低血浆IL-1β含量，进而影响其免疫功能。
Objective To investigate the effects of intrauterine growth retardation (IUGR) on immune organs and plasma cytokine contents in growing-finishing pigs.Method A total of 36 pregnant sows with similar body conditions were selected. After delivery, one IUGR piglet (IUGR group) and one normal born weight piglet (control group) were selected from each litter, respectively. After weaning, the animals were fed with the same basic diet. When the average body weight (BW) of control pigs gained 25, 50 and 100 kg, seven pigs per group were randomly selected to collect blood samples by precaval vein, and plasma cytokine contents were measured. Twelve pigs in each group were killed for isolating and weighing liver, spleen, and kidney to calculate their organ indices.Result Compared to the control group with the same BW, the liver, spleen and kidney weights of IUGR pigs decreased by 32.63%, 35.07% and 34.28% at 25 kg BW stage (P<0.01) and decreased by 22.68%, 40.05% and 33.03% at 50 kg BW stage, respectively. The content of plasma interleukin IL-1β in IUGR pigs at 25 and 50 kg BW stages decreased by 20.66% and 27.21% (P<0.05), respectively. Compared to the control group at 50 kg BW stage, the liver index of IUGR pigs increased by 16.25% (P<0.05) and the ratio of IL-1β to IL-10 decreased by 40.67% (P<0.01). Compared to the control group at 100 kg BW stage, the liver index and spleen index of IUGR pigs increased by 10.94% (P<0.05) and 21.74% (P<0.01), respectively, while the liver weight and kidney weight decreased by 13.97% and 17.51% (P<0.01), respectively.Conclusion IUGR can alter the organ indices and weights of liver, spleen and kidney, decrease plasma IL-1β content, and therefore influences the immune function in growing-finishing pigs.