The revitalization of seed industry is of great strategic significance to ensure national food security. For promoting the revitalization of Chinese seed industry to ensure food security, we must adhere to the view of great territory and greater food approach (GFA), solve the “strangle hold” problem of seed industry under the dynamic development pattern, pay attention to the necessary matching conditions to revitalize the seed industry considering the coordinated development, and expand the development space to revitalize the seed industry under the perspective of international competition and cooperation. This article revealed the fundamental, critical and decisive roles of seed industry revitalization from the perspective of the priority of factors affecting food security. The development process of Chinese seed industry was reviewed and the relationship between food security and seed industry revitalization was clarified. Under the new pattern of food security, the connotation and challenge of seed industry revitalization were analyzed under the GFA. Some countermeasures and suggestions were put forward for the healthy and orderly development of Chinese seed industry revitalization in the future.