覃柳琪,董先明,苏祥郁,周武艺,郑文旭.生物基聚乳酸复合材料3D打印制备含微孔支架及性能研究[J].华南农业大学学报,2022,43(1):37-43
生物基聚乳酸复合材料3D打印制备含微孔支架及性能研究
Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites
投稿时间:2021-06-10  
DOI:10.7671/j.issn.1001-411X.202106012
中文关键词:  熔融共混  3D打印  支架  聚乳酸  生物基材料
英文关键词:Melt blending  3D printing  Scaffold  Polylactic acid  Bio-based material
基金项目:广东省科技厅国际合作项目(2020A0505100050);广东省自然科学基金(2020A1515011004);广东普通高校新冠肺炎疫情防控科研专项(2020KZDZX1035)
作者单位E-mail
覃柳琪 生物基材料与能源教育部重点实验室广东 广州510642
华南农业大学 材料与能源学院广东 广州510642 
 
董先明 生物基材料与能源教育部重点实验室广东 广州510642
华南农业大学 材料与能源学院广东 广州510642 
 
苏祥郁 华南农业大学 材料与能源学院广东 广州510642  
周武艺 生物基材料与能源教育部重点实验室广东 广州510642
华南农业大学 材料与能源学院广东 广州510642 
zhouwuyi@scau.edu.cn 
郑文旭 生物基材料与能源教育部重点实验室广东 广州510642
华南农业大学 材料与能源学院广东 广州510642 
wzheng@scau.edu.cn 
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中文摘要:
      目的 探讨生物基聚乳酸复合材料用于3D打印直接构建含微孔支架的可行性。方法 采用热重分析仪和差示扫描量热仪探究聚乳酸复合材料的热性能,扫描电镜表征支架的微观形貌,活/死细胞染色检测支架的细胞黏附情况。结果 所制备的0.6%ADC-PHAP和40%NaCl-PHAP复合材料具有良好的热稳定性和加工性,适用于熔融沉积3D打印。当压缩应变为80%时,0.6%ADC-PHAP和40%NaCl-PHAP支架相应的压缩应力分别为45.27和52.11 MPa;0.6%ADC-PHAP复合材料的初始分解温度比40%NaCl-PHAP复合材料低19.5 ℃;0.6%ADC-PHAP支架的孔隙率达到63.33%,有利于细胞黏附,且细胞相容性比40%NaCl-PHAP支架更好。结论 生物基聚乳酸复合材料可通过熔融沉积型3D打印直接构建含微孔支架,所制备的0.6%ADC-PHAP支架具有一定的应用潜力。
英文摘要:
      Objective To explore the feasibility of using bio-based polylactic acid composites to directly construct microporous scaffolds by 3D printing.Method Thermogravimetric analyzer and differential scanning calorimeter were used to explore the thermal properties of bio-based polylactic acid composites, scanning electron microscopy was used to characterize the microscopic morphology of the bio-scaffold, and the live/dead cell staining was used for detecting cell adhesion of the scaffold. Result The prepared 0.6%ADC-PHAP and 40%NaCl-PHAP composites had good thermal stability and processability, and were suitable for the fused deposition modeling 3D printing process. When the compressive strain was 80%, the corresponding compressive stresses of the 0.6%ADC-PHAP and 40%NaCl-PHAP scaffolds were 45.27 and 52.11 MPa, respectively. The initial decomposition temperature of the 0.6%ADC-PHAP composite was 19.5 ℃ lower than that of the 40%NaCl-PHAP composite. The porosity of the 0.6%ADC-PHAP scaffold reached 63.33% which was conducive to cell adhesion, and the cell compatibility was better than that of the 40%NaCl-PHAP scaffold. Conclusion The bio-based polylactic acid composites can be used to directly construct microporous bio-scaffolds through fused deposition modeling 3D printing, and the prepared 0.6%ADC-PHAP bio-scaffold has certain application potential.
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